Magnesium Counteracts Vascular Calcification
نویسندگان
چکیده
منابع مشابه
Magnesium Counteracts Vascular Calcification
Cardiovascular disease is the leading cause of mortality in patients with chronic kidney disease (CKD). Cardiovascular events are 5 to 30× more likely to occur in end-stage renal disease (ESRD) patients compared with the general population of the same age, sex, and race. In dialysis patients, arterial stiffness has been identified as an independent risk factor for cardiovascular mortality. An i...
متن کاملMagnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells
BACKGROUND Vascular calcification (VC) is prevalent in patients suffering from chronic kidney disease. Factors promoting calcification include abnormalities in mineral metabolism, particularly high phosphate levels. Inorganic phosphate (Pi) is a classical inducer of in vitro VC. Recently, an inverse relationship between serum magnesium concentrations and VC has been reported. The present study ...
متن کاملMagnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease.
Chronic kidney disease (CKD) patients are commonly treated with vitamin D analogs, such as calcitriol. Recent epidemiologic evidence revealed a significant interaction between vitamin D and magnesium, since an inverse relationship between vitamin D levels and mortality mainly occurs in patients with a high magnesium intake. The aim of the study was to assess the mechanisms involved by determini...
متن کاملMagnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner
BACKGROUND Vascular calcification (VC), mainly due to elevated phosphate levels, is one major problem in patients suffering from chronic kidney disease. In clinical studies, an inverse relationship between serum magnesium and VC has been reported. However, there is only few information about the influence of magnesium on calcification on a cellular level available. Therefore, we investigated th...
متن کاملA Magnesium Based Phosphate Binder Reduces Vascular Calcification without Affecting Bone in Chronic Renal Failure Rats
The alternative phosphate binder calcium acetate/magnesium carbonate (CaMg) effectively reduces hyperphosphatemia, the most important inducer of vascular calcification, in chronic renal failure (CRF). In this study, the effect of low dose CaMg on vascular calcification and possible effects of CaMg on bone turnover, a persistent clinical controversy, were evaluated in chronic renal failure rats....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2017
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.117.309182